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When participants who had been taking semaglutide were randomized to either continue the medication or switch to placebo after 20 weeks, those who continued treatment maintained their weight loss, while those switched to placebo regained significant weight

PubMed Central, Accessed 12 Apr

Leptin, a key regulator of satiety and appetite, is decreased in active IBD, probably due to exhaustion after transient overproduction related to TNF- hyperactivity

This hormone plays an essential role in managing blood sugar levels and appetite regulation